Projecten
Nieuw nanotechnologie-geschikt systeem voor endovasculaire in vivo nabij-infrarood fluorescentie moleculaire beeldvorming en endovasculaire nabij-infrarood gerichte fotodynamische therapie van atherosclerotische hartziekte. KU Leuven
CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives:
- develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic therapy, real-time & follow-up ...
Lungtarget KU Leuven
B-specific: B-celgerelateerde gen- en eiwitmarkers met prognostische en therapeutische waarde voor hart-en vaatziekten KU Leuven
Atherosclerosis is the major underlying condition of cardiovascular disease (CVD) and one the leading causes of mortality. Rupture or erosion of atherosclerotic lesions can lead to acute cardiovascular events, such as myocardial infarction and stroke, making biomarkers to diagnose patients at risk for these events and develop tailored preventive interventions, an urgent need. Although atherosclerosis is a chronic inflammatory disease, ...
Metrologie voor opkomende gerichte alfatherapieën KU Leuven
Targeted alpha therapy (TAT) is a rapidly growing cancer treatment modality, whereby alpha-emitting radiopharmaceuticals selectively target tumours whilst minimising the radiation to healthy tissues. Presently only 223RaCl2 has regulatory approval, but its success resulted in unprecedented levels of interest and investment in TAT for a variety of cancers. It is showing promising efficacy and increased survival in clinical trials; however, ...
Het gentherapie-innovatietrainingsnetwerk KU Leuven
Gene therapy has transitioned from a distant hope to reality. To date 3 rAAV gene therapies are approved in the EU, >30 phase III clinical trials ongoing, and exciting developments in therapeutic gene editing in the pipeline. However, fundamental limitations in the bioprocessing of gene therapy vectors limit broader application. Manufacturing is not automated, with an open process environment, limited scalability and robustness, and ...
Cystic Fibrosis microbioom-bepaald antibioticatherapieonderzoek bij exacerbaties: resultaten gestratificeerd. KU Leuven
Antimicrobial resistance is arguably the most significant challenge facing the EU health care system. The unnecessary use of antibiotics is a key driver in the development of antibiotic resistance. Cystic Fibrosis (CF) represents a unique disease model to study bacterial resistance and to explore therapeutic strategies for same, as chronic lung infection overlaps with acute lung exacerbations caused by a multitude of organisms that ...
Betere controle en behandeling van immuun-gemedieerde ziekten door het universum van door micro-omgeving opgelegde weefselsignaturen en hun correlaten in vloeibare biopten te verkennen KU Leuven
mmune-mediated diseases (IMIDs) are an increasing medical burden in industrialized countries worldwide. IMIDs are characterized by an enormous heterogeneity with regard to disease outcome and response to targeted therapies, which currently cannot be adequately anticipated to tailor individual patient management. Hence, mechanistic understanding of this heterogeneity and biomarkers predictive for disease control and therapy response over time ...
Akoestische markers voor verbeterde remote sensing van stralingsdoses KU Leuven
Approximately 50% of all cancer patients receive radiation therapy as part of their treatment. The aim is hereby to maximise tumor irradiation and to minimize healthy tissue irradiation. This implies a need for appropriate dosimetry strategies that can effectively measure the actual radiation dose imparted on the tumor. However, state-of-the-art dosimetry cannot quantify the dose distribution in (and around) the tumor, hereby inhibiting the ...
Ontwikkeling van stimuli-responsieve nanodeeltjes dragende T-lymfocyten in de strijd tegen kanker. KU Leuven
The cancer burden represents an overarching health problem and it is essential that EU institutions develop the next generation of diagnostics that overcome the inadequacy of current imaging strategies. Nanomedicine, defined as the use of nanotechnologies in medicine, offers extraordinary opportunities to address these unmet medical needs.
The proposed research project endeavours to find effective anticancer diagnostics through the ...