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Identification of potential antivirulence agents by substitution- oriented screening for inhibitors of Streptococcus pyogenes sortase A KU Leuven
Antimicrobial resistance resulting in ineffective treatment of infectious diseases is an increasing global problem, particularly in infections with pathogenic bacteria. In some bacteria, such as Streptococcus pyogenes, the pathogenicity is strongly linked to the attachment of virulence factors. Their attachment to the cellular membrane is a transpeptidation reaction, catalyzed by sortase enzymes. As such, sortases pose an interesting target for ...
Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments Vrije Universiteit Brussel Universiteit Gent
A generic site-specific conjugation method that generates a homogeneous product is of utmost importance in tracer development for molecular imaging and therapy. We explored the protein-ligation capacity of the enzyme Sortase A to label camelid single-domain antibody-fragments, also known as nanobodies. The versatility of the approach was demonstrated by conjugating independently three different imaging probes: the chelating agents CHX-A"-DTPA ...
Differences in collagen type distribution in ruptured aortas of Friesian horses vs. aortas of healthy Friesian and Warmblood horses Universiteit Gent
Analysis of Malus S-RNase gene diversity based on a comparative study of old and modern apple cultivars and European wild apple Instituut voor Landbouw-, Visserij- en Voedingsonderzoek Universiteit Gent KU Leuven
Malus S-RNase genetic diversity was analyzed in Malus x domestica cultivars and compared to European wild apple (Malus sylvestris). Using PCR-based approaches, the S-RNase genotype of 140 M. x domestica cultivars, 196 M. sylvestris trees and 27 M. sylvestris-M. x domestica hybrids was determined. S-RNase allelic richness in M. sylvestris was much higher than in M. x domestica, indicating the negative influence of domestication on S-RNase ...
Polynomial-time sortable stacks of burnt pancakes KU Leuven
Pancake flipping, a famous open problem in computer science, can be formalised as the problem of sorting a permutation of positive integers using as few prefix reversals as possible. In that context, a prefix reversal of length k reverses the order of the first k elements of the permutation. The burnt variant of pancake flipping involves permutations of signed integers, and reversals in that case not only reverse the order of elements but also ...
Farmers' adaptation to groundwater shortage in the dry areas : improving appropriation or enhancing accommodation? Universiteit Gent
Can presumed consent overcome organ shortage in India? Lessons from the Belgian experience Vrije Universiteit Brussel
Looking at the Indian deceased donation model by working closely with counselors of MOHAN Foundation in Chennai and Hyderabad and using the background knowledge of the implementation of presumed consent in Belgium, the authors in this article reflect on the question whether such a model could be feasible in India.