Publicaties
Case report: visceral leishmaniasis with Salmonella paratyphi and Brucella melitensis coinfection as a cause of persistent fever in a patient from Sudan Instituut voor Tropische Geneeskunde KU Leuven
We describe the case of a 12-year-old boy from Sudan who presented with fever of 1-week duration, headache, cough, and vomiting. A set of diagnostic tests led to the diagnosis of three infectious diseases: visceral leishmaniasis (probable diagnosis based on positive direct agglutination test), enteric fever (blood culture grown with Salmonella Paratyphi), and brucellosis (blood culture grown with Brucella melitensis). The patient received ...
Epidemiological and clinical characteristics of international travelers with enteric fever and antibiotic resistance profiles of their isolates: a GeoSentinel analysis Instituut voor Tropische Geneeskunde
Enteric fever, caused by Salmonella enterica serovar Typhi ( S Typhi) and S. enterica serovar Paratyphi ( S Paratyphi), is a common travel-related illness. Limited data are available on the antimicrobial resistance (AMR) patterns of these serovars among travelers. Records of travelers with a culture-confirmed diagnosis seen during or after travel from January 2007 to December 2018 were obtained from GeoSentinel. Traveler demographics and ...
The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015 Instituut voor Tropische Geneeskunde KU Leuven Universiteit Antwerpen
BACKGROUND: Enteric fever remains a major public health problem in low resource settings and antibiotic resistance is increasing. In Asia, an increasing proportion of infections is caused by Salmonella enterica serovar Paratyphi A, which for a long time was assumed to cause a milder clinical syndrome compared to Salmonella enterica serovar Typhi.
METHODOLOGY: A retrospective chart review study was conducted of 254 unique cases of ...
Diagnosis of persistent fever in the tropics Instituut voor Tropische Geneeskunde KU Leuven
In resource-limited settings, the scarcity of skilled personnel and adequate laboratory facilities makes the differential diagnosis of fevers complex [1-5]. Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid Diagnostic Tests (RDTs) and clinical algorithms can be valuable aids to health workers and facilitate therapeutic decisions [6,7]. The persistent fever syndrome targeted by NIDIAG is defined as presence of ...
Ongoing outbreak of Salmonella enterica serovar Paratyphi A infections, Phnom Penh, Cambodia [letter] Instituut voor Tropische Geneeskunde KU Leuven Universiteit Antwerpen
Increase in Salmonella enterica serovar paratyphi A infections in Phnom Penh, Cambodia, January 2011 to August 2013 Instituut voor Tropische Geneeskunde
Phylogenomic investigation of an outbreak of fluoroquinolone- resistant Salmonella enterica subsp. enterica serovar Paratyphi A in Phnom Penh, Cambodia KU Leuven Instituut voor Tropische Geneeskunde
Genomic analysis of Salmonella enterica serotype Paratyphi A during an outbreak in Cambodia, 2013-2015 Instituut voor Tropische Geneeskunde Universiteit Antwerpen KU Leuven
In 2013, an unusual increase in the number of Salmonella enterica serotype Paratyphi A (Salmonella Paratyphi A) infections was reported in patients in Phnom Penh, Cambodia, and in European, American and Japanese travellers returning from Cambodia. Epidemiological investigations did not identify a common source of exposure. To analyse the population structure and genetic diversity of these Salmonella Paratyphi A isolates, we used whole-genome ...
Gatifloxacin versus ofloxacin for the treatment of uncomplicated enteric fever in Nepal: an open-label, randomized, controlled trial Instituut voor Tropische Geneeskunde
BACKGROUND: Fluoroquinolones are the most commonly used group of antimicrobials for the treatment of enteric fever, but no direct comparison between two fluoroquinolones has been performed in a large randomised trial. An open-label randomized trial was conducted to investigate whether gatifloxacin is more effective than ofloxacin in the treatment of uncomplicated enteric fever caused by nalidixic acid-resistant Salmonella enterica serovars ...