Publicaties
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Oral administration of beta-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM KU Leuven Universiteit Gent
The effect of oral administration of beta-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this beta-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as ...
Measurements of the pp → Wγγ and pp → Zγγ cross sections and limits on anomalous quartic gauge couplings at √s=8 TeV Universiteit Gent Vrije Universiteit Brussel Universiteit Antwerpen
Measurements are presented of W gamma gamma and Z gamma gamma production in proton-proton collisions. Fiducial cross sections are reported based on a data sample corresponding to an integrated luminosity of 19.4 fb(-1) collected with the CMS detector at a center-of-mass energy of 8 TeV. Signal is identified through the W -> lv and Z -> ll decay modes, where l is a muon or an electron. The production of W gamma gamma and Z gamma gamma, ...
Porcine IgG : structure, genetics, and evolution. Vrije Universiteit Brussel
Eleven genomic porcine Cgamma gene sequences are described that represent six putative subclasses that appear to have originated by gene duplication and exon shuffle. The genes previously described as encoding porcine IgG1 and IgG3 were shown to be the IgG1a and IgG1b allelic variants of the IgHG1 gene, IgG2a and IgG2b are allelic variants of the IGHG2 gene, while "new" IgG3 is monomorphic, has a exteded hinge, is structurally unique, and ...
Evaluation of the New Architect Cytomegalovirus Immunoglobulin M (IgM), IgG, and IgG Avidity Assays KU Leuven
A panel of new cytomegalovirus (CMV) assays for use on the Architect instrument has been developed, including a CMV avidity assay based on a new technology. The purpose of this study was to compare the performance characteristics of the fully automated CMV immunoglobulin M (IgM), IgG, and IgG avidity tests on the Architect instrument with those of other available assays. A total of 503 consecutive fresh patient serum specimens (routine serum ...
Igg Subclass Composition of Autoantibodies to Two Novel Peptides in Early and Seronegative Rheumatoid Arthritis Universiteit Hasselt
Background Previously, we identified autoantibodies to novel University of Hasselt (UH) peptides in early and seronegative rheumatoid arthritis (RA)1. Autoantibody responses against two of these peptides, UH-RA.1 and UH-RA.21, were validated in two large European cohorts (Hasselt University (UH) and Leiden Early Arthritis Clinic cohorts), resulting in the identification of 18-22% of RF-negative and ACPA-negative RA patients and up to one third ...
Aspergillus-Specific IgG Antibodies are Associated With Fungal-Related Complications and Chronic Lung Allograft Dysfunction After Lung Transplantation KU Leuven
Fungal exposure and sensitization negatively affect outcomes in various respiratory diseases, however, the effect of fungal sensitization in lung transplant (LTx) recipients is still unknown. We performed a retrospective cohort study of prospectively collected data on circulating fungal specific IgG/IgE antibodies, and their correlation with fungal isolation, chronic lung allograft dysfunction (CLAD) and overall survival after LTx. 311 patients ...
Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct Vrije Universiteit Brussel
Camelid ungulates produce homodimeric heavy chain-only antibodies (HCAbs) in addition to conventional antibodies consisting of paired heavy and light chains. In the llama, HCAbs are made up by at least two subclasses (long-hinge IgG2b and short-hinge IgG2c HCAbs vs. conventional heterotetrameric IgG1s). Here, we generated murine monoclonal antibodies (mAbs) specific for the hinge-C H 2 boundary of llama IgG2b (mAb 1C10) and the Fc of llama ...
Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis compared to the reference standard Universiteit Gent
Objectives: To evaluate the performance of Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis (CPA) by using a cohort of patients with histologically proven CPA as a reference standard.Methods: We collected Aspergillus-specific IgG antibody titres from patients with histologically proven CPA in collaboration with CPAnet study sites in Denmark, Germany, Belgium, India, Moldova, and Pakistan (N = 47). Additionally, ...