Plasma GAD65, marker for early beta cell loss following intraportal islet cell transplantation in diabetic patients Vrije Universiteit Brussel KU Leuven
CONTEXT AND OBJECTIVE: Intraportal islet transplantation can restore insulin production in type 1 diabetes patients but its effect is subject to several interfering processes. To assess the influence of beta-cell loss before and during engraftment we search for a real-time marker of beta-cell destruction. Previous studies showed that GAD65 is discharged by chemically damaged rat beta cells. We therefore examined the utility of the GAD65 assay ...