Adaptation of Mycobacterium tuberculosis to impaired host immunity in HIV-infected patients Instituut voor Tropische Geneeskunde
Background. It is unknown whether immunosuppression influences the physiologic state of Mycobacterium tuberculosis in vivo. We evaluated the impact of host immunity by comparing M. tuberculosis and human gene transcription in sputum between human immunodeficiency virus (HIV)-infected and uninfected patients with tuberculosis.
Methods. We collected sputum specimens before treatment from Gambians and Ugandans with pulmonary ...