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Pyrene‐based covalent organic frameworks for photocatalytic hydrogen peroxide production Universiteit Gent
Four highly porous covalent organic frameworks (COFs) containing pyrene units were prepared and explored for photocatalytic H2O2 production. The experimental studies are complemented by density functional theory calculations, proving that the pyrene unit is more active for H2O2 production than the bipyridine and (diarylamino)benzene units reported previously. H2O2 decomposition experiments verified that the distribution of pyrene units over a ...
N‐rich porous polymer with isolated Tb3+‐ions displays unique temperature dependent behavior through the absence of thermal quenching Universiteit Gent
The challenge of measuring fast moving or small scale samples is based on the absence of contact between sample and sensor. Grafting lanthanides onto hybrid materials arises as one of the most promising accurate techniques to obtain noninvasive thermometers. In this work, a novel bipyridine based porous organic polymer (bpyDAT POP) was investigated as temperature sensor after grafting with Eu(acac)(3)and Tb(acac)(3)complexes. The bpyDAT POP ...
Metal- and covalent organic frameworks as catalyst for organic transformation : comparative overview and future perspectives Universiteit Gent
A green alternative for the direct aerobic iodination of arenes using molecular iodine and a POM@MOF catalyst Universiteit Gent
Iodoarenes are important precursors for fine chemicals and pharmaceuticals. The direct iodination of arenes using molecular iodine (I2) has emerged as an attractive green synthesis method. Most of the direct iodination protocols are still homogeneous systems that require harsh conditions and use or produce toxic products. We report a new heterogeneous catalytic route for the direct aerobic iodination of arenes under mild conditions using a PMoV2 ...
Unveiling the potential of innovative gold(I) and silver(I) selenourea complexes as anticancer agents targeting TrxR and cellular redox homeostasis Universiteit Gent
A series of NHC-based selenourea Ag(I) and Au(I) complexes were evaluated for their anticancer potential in vitro, on 2D and 3D human cancer cell systems. All NHC-based selenourea complexes possess an outstanding cytotoxic potency, which was comparable or even better than that of the reference metallodrug auranofin, and were also able to overcome both platinum-based and multi-drug resistances. Intriguingly, their cytotoxic potency did not ...
Covalent triazine frameworks : metal-free heterogeneous (photo)catalysts Universiteit Gent
Palladium‐Catalyzed Domino Synthesis of 2,3‐Difunctionalized Indoles via Migratory Insertion of Isocyanides in Batch and Continuous Flow KU Leuven
We report, herein, a palladium‐catalyzed cascade comprising carbopalladation, migratory insertion of isocyanide and triple bond activation followed by a nucleophilic attack (OR‐) to construct difunctionalized acyl indoles. The process involves multiple bond formations via key palladium‐chemistry steps, to construct these bis‐heterocycles containing two privileged scaffolds (indole and oxindole) in a single operational step, along with attempts ...
Visible-Light-Induced Cascade Difunctionalization of Indoles Enabled by the Synergy of Photoredox and Photoexcited Ketones: Direct Access to Alkylated Pyrrolophenanthridones KU Leuven
Herein, we describe a methodology to construct polycyclic pyrrolophenanthridones with an (amino)alkyl side chain that involves visible-light-induced decarboxylative radical addition for the intermolecular dearomatization of indoles and subsequent photoinduced C(sp2)-X bond activation via photoexcited ketones for an intramolecular cyclization cascade. Carboxylic acids serve both as a radical source toward indole dearomatization and as reductants ...
Visible-Light-Driven Palladium-Catalyzed Radical Tandem Dearomatization of Indoles with Unactivated Alkenes KU Leuven
A mild visible-light-driven palladium-catalyzed radical tandem dearomatization of indoles with unactivated alkenes is described with moderate to good yields and good to excellent diastereoselectivities. Under visible-light irradiation, the photoexcited state of the palladium complex was formed, which could transfer a single electron to N-(2-bromobenzoyl)indoles, leading to a hybrid palladium radical chemistry. This provides efficient and ...