Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity Vrije Universiteit Brussel
Direct communication between hepatocytes, mediated by gap junctions, constitutes a major regulatory platform in the control of liver homeostasis, ranging from hepatocellular proliferation to hepatocyte cell death. Inherent to this pivotal task, gap junction functionality is frequently disrupted upon impairment of the homeostatic balance, as occurring during liver toxicity and carcinogenicity. In the present paper, the deleterious effects of a ...