Better clinical management of Visceral Leishmaniasis in HIV patients in Ethiopia: secondary prophylaxis and HAART optimization. Instituut voor Tropische Geneeskunde
Asrat Hailu, Bob Colebunders, Lut Lynen
BACKGROUND: The clinical management of HIV/leishmaniasis co-infected patients is challenging, as both pathogens undermine host immunity in a synergistic way, leading to very poor clinical outcomes even under HAART therapy, with repeated relapses of VL. The use of secondary prophylaxis for prevention of VL relapse was promising in some studies in Europe but was not yet tested in an African setting. Though the antileishmania effect of HIV protease ...