Mlv-based gene therapy with mutated integrase coupled to peptides KU Leuven
The invention relates to gamma retroviral plasmids comprising a nucleotide sequence which codes for a gamma-retroviral-Integrase (IN), which is independent from bromodomain and extra-terminal (BET) family of proteins, wherein said nucleotide is operably linked to a nucleotide sequence which codes for a chromatin binding domain (CBD) or a chromatin binding fragment thereof.