Publicaties
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Iohexol plasma clearance for measuring glomerular filtration rate: effect of different ways to calculate the area under the curve KU Leuven
BACKGROUND: Measuring glomerular filtration rate (GFR) using iohexol plasma clearance has been proposed as the preferred way for GFR determination. The extended multiple-sample protocol is based on fitting the full concentration-time decay-curve, and from the obtained fit-parameters, the area under the curve (AUC) and GFR (the injected dose divided by the AUC) were calculated. The goal of the current study is to evaluate the impact of different ...
Impact of longer term phosphorus control on cardiovascular mortality in hemodialysis patients using an area under the curve approach: results from the DOPPS KU Leuven
BACKGROUND: Serial assessment of phosphorus is currently recommended by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, but its additional value versus a single measurement is uncertain. METHODS: We studied data from 17 414 HD patients in the Dialysis Outcomes and Practice Patterns Study, a prospective cohort study, and calculated the area under the curve (AUC) by multiplying the time spent with serum phosphorus >4.5 mg/dL ...
CA 15.3 measurements for separating FDG PET/CT positive from negative findings in breast carcinoma recurrence. Factors influencing the area under the ROC curve KU Leuven Universiteit Gent
In breast cancer CA 15.3 is considered the tumour marker of choice. CA 15.3 is directly related to the disease extent and to hormone status (estrogen receptor ER+/ ER-, progesterone receptor PR+/PR-). This study was designed to assess the impact of disease extent, hormone receptor and HER2-status, and circulating blood volume on the area-under the ROC-curve of CA 15.3 to separate FDG PET positive from negative findings.
Limited sampling models and Bayesian estimation for mycophenolic acid area under the curve prediction in stable renal transplant patients co-medicated with ciclosporin or sirolimus Universiteit Antwerpen
Background and Objective: Mycophenolate mofetil is a prodrug of mycophenolic acid (MPA), an immunosuppressive agent used in combination with corticosteroids and calcineurin inhibitors or sirolimus for the prevention of acute rejection after solid organ transplantation. Although MPA has a rather narrow therapeutic window and its pharmacokinetics show considerable intra- and interindividual variability, dosing guidelines recommend a standard ...
Area under forced expiratory flow-volume loop in spirometry is a superior marker for severe static hyperinflation in COPD patients KU Leuven
Background: Severe hyperinflation causes detrimental effects such as dyspnea and reduced exercise capacity and is an independent predictor of mortality in COPD patients. Static lung volumes are required to diagnose severe hyperinflation, which are not always accessible in primary care. Several studies have shown that the area under the forced expiratory flow-volume loop (AreaFE) is highly sensitive to bronchodilator response and is correlated ...
Canopy cover evolution, diurnal patterns and leaf area index relationships in a Mchare and Cavendish banana cultivar under different soil moisture regimes KU Leuven
The biggest abiotic threat to banana (Musa spp.) production is water deficit, but physiological indicators in plantations are lacking. Canopy Cover (CC) seems to be a relevant parameter, but so far not used in banana fields. Field experiments were conducted to determine the effect of optimal irrigation (FI) versus rainfed (RF) on CC and Leaf Area Indices (LAI) in two experiments with different cultivars (Mchare ‘Huti Green’ [HG, AA] and ...
Application of ROC curve analysis to FAMACHA((c)) evaluation of haemonchosis on two sheep farms in South Africa Instituut voor Tropische Geneeskunde
Test sensitivity and specificity for the FAMACHA((c)) clinical test for anaemia due to haemonchosis have previously been shown to be adequate in differentiating between heavily/less heavily infected sheep, but these properties give no objective guidance for setting the optimum threshold at which anthelmintic treatment should occur. The aim of this work was to use Receiver Operating Characteristic (ROC) curves to evaluate the diagnostic accuracy ...