Publicaties
ELISA HTLV retrovirus antibody reactivity associated with malaria and immune complexes in healthy Africans Instituut voor Tropische Geneeskunde
Modeling antibody dynamics following herpes zoster indicates that higher varicella-zoster virus viremia generates more VZV-specific antibodies Universiteit Hasselt Universiteit Antwerpen
An immobilized antibody targeting N-cadherin facilitates spread of N-cadherin-positive tumour cells Universiteit Gent
A non-internalised CD38-binding radiolabelled single-domain antibody fragment to monitor and treat multiple myeloma Vrije Universiteit Brussel
BACKGROUND: Antibody-based therapies targeting CD38 are currently used as single agents as well as in combination regimens for multiple myeloma, a malignant plasma cell disorder. In this study, we aimed to develop anti-CD38 single-domain antibodies (sdAbs) that can be used to trace CD38+ tumour cells and subsequently used for targeted radionuclide therapy. SdAbs are derived from Camelidae heavy-chain antibodies and have emerged as promising ...
Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation Vrije Universiteit Brussel
PURPOSE: Our previous studies with F-18-labeled anti-HER2 single-domain antibodies (sdAbs) utilized 5F7, which binds to the same epitope on HER2 as trastuzumab, complicating its use for positron emission tomography (PET) imaging of patients undergoing trastuzumab therapy. On the other hand, sdAb 2Rs15d binds to a different epitope on HER2 and thus might be a preferable vector for imaging in these patients. The aim of this study was to ...
Recent developments in engineering and delivery of protein and antibody therapeutics Vrije Universiteit Brussel
enzymes, vaccines, and antibodies, are increasingly important in
health care practice and already represent a very significant portion of
the revenues for the pharmaceutical industry. Obviously, these settings
make it evident that identifying new bio-therapeutics, improving their
production, delivery method and functional properties, are ...
Dual beneficial effect of an interloop disulfide bond for single domain antibody gragments. Vrije Universiteit Brussel
Screening for Trypanosoma brucei gambiense antibodies with the indirect fluorescent antibody test (IFAT); effect of age and previous treatment Instituut voor Tropische Geneeskunde
Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants Instituut voor Tropische Geneeskunde
BACKGROUND: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccines are less effective than in high income settings. To establish whether there is an association between these two observations, we tested the hypothesis that infection with one or both viruses ...