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De dag en het uur van het breken van het brood KU Leuven
In het laatste hoofdstuk van zijn evangelie (Lc 24) laat Lucas Jezus op de dag van de verrijzenis dit is op de eerste dag van de week (Lc 24,1.13) de Schriften uitleggen en het brood breken tegen de avond (Lc 24,29). Deze twee handelingen doen spontaan denken aan de tweeledige structuur van de eucharistie, waarbij de Schrift wordt voorgelezen en uitgelegd en het brood wordt gebroken. Hier rijzen meteen onze twee onderzoeksvragen: (1) Is Lucas ...
Non-invasive Bioluminiscence Imaging of Myobast-Mediated Hypoxia-Inducible Factor-1 Alpha Gene Transfer KU Leuven
PURPOSE: We tested a novel imaging strategy, in which both the survival of transplanted myoblasts and their therapeutic transgene expression, a recombinant hypoxia-inducible factor-1α (HIF-1α-VP2), can be monitored using firefly luciferase (fluc) and Renilla luciferase (hrl) bioluminescence reporter genes, respectively. PROCEDURES: The plasmid pUbi-hrl-pUbi-HIF-1α-VP2, which expresses both hrl and HIF-1α-VP2 using two ubiquitin promoters, was ...
Imaging in cervical nodal metastases of unknown primary. KU Leuven
In patients presenting with a neck adenopathy from a clinically unknown primary, efforts should be made to localize the primary tumour, as this allows a more focused therapy. Imaging is helpful in identifying suspicious mucosal sites that should be further investigated endoscopically, including biopsy. In case no primary tumour is detected in the head and neck, a positron emission tomography (PET) study can be considered to search for an ...
Indoor millimetre wave synthetic aperture radar (SAR) imaging: modelling and system studies KU Leuven
Synthetic Aperture Radar (SAR) imaging is playing an important role nowadays. Moreover, with the development of fabrication and simulation techniques, activities at millimetre wave (mmW) frequencies are booming. Consequently, millimetre SAR imaging becomes a hot topic. However, due to the cost of equipments, it is not always feasible to build such an experimental setup for studies. For ease of system studies, we have developed a simulation tool ...
3-D antenna-in-packaging solution for microwave wireless sensor networks nodes KU Leuven
A three-dimensional packaging solution is introduced for wireless sensor network nodes at microwave frequencies. The package has a cubic geometry with radiating antennas on its surrounding faces. The cube which is called e-CUBE is designed in such a way that its radiation pattern resembles that of a simple dipole. The antenna is designed in a modular way and the final structure has a return loss better than 10 dB and a dipole-shape pattern at ...
Early time points perfusion imaging: Relative time of arrival, maximum derivatives and fractional derivatives KU Leuven
Time of arrival (TOA) of a bolus of contrast agent to the tissue voxel is a reference time point critical for the Early Time Points Perfusion Imaging Method (ET) to make relative cerebral blood flow (rCBF) maps. Due to the low contrast to noise (CNR) condition at TOA, other useful reference time points known as relative time of arrival data points (rTOA) are investigated. Candidate rTOA's include the time to reach the maximum derivative, the ...
Search for Same-Sign Top-Quark Pair Production at sqrt(s) = 7 TeV and Limits on Flavour Changing Neutral Currents in the Top Sector. Vrije Universiteit Brussel
An inclusive search for same-sign top-quark pair production in pp collisions at sqrt(s) = 7 TeV is performed using a data sample recorded with the CMS detector in 2010, corresponding to an integrated luminosity of 35 inverse picobarns. This analysis is motivated by recent studies of p p-bar to t t-bar reporting mass-dependent forward-backward asymmetries larger than expected from the standard model. These asymmetries could be due to Flavor ...
Precinical screening of anti-HER2 nanobodies for molecular imaging of breast cancer. Vrije Universiteit Brussel
Accurate determination of tumor human epidermal growth factor receptor 2 (HER2)-status in breast cancer patients is possible via noninvasive imaging, provided adequate tracers are used. In this study, we describe the generation of a panel of 38 nanobodies, small HER2-binding fragments that are derived from heavy-chain-only antibodies raised in an immunized dromedary. In search of a lead compound, a subset of nanobodies was biochemically ...
Novel DOTA-Neurotensin Analogues for In-111 Scintigraphy and Ga-68 PET Imaging of Neurotensin Receptor-Positive Tumors Vrije Universiteit Brussel
Abstract: Overexpression of the high affinity neurotensin receptor 1 (NTSR1), demonstrated in several human cancers, has been proposed as a new marker for human ductal pancreatic carcinoma and as an independent factor for poor prognosis for ductal breast cancer, head and neck squamous cell carcinoma, and non-small cell lung cancer. The aim of the present study was to develop new DOTA-neurotensin analogues for positron emission tomography (PET) ...