Silencing of the secretory pathway Ca2+- ATPase isoform 1 (SPCA1) impairs Ca2+ homeostasis in the Golgi and disturbs neural polarity KU Leuven
Neural cell differentiation involves a complex regulatory signal transduction network in which Ca(2+) ions and the secretory pathway play pivotal roles. The secretory pathway Ca(2+)-ATPase isoform 1 (SPCA1) is found in the Golgi apparatus where it is actively involved in the transport of Ca(2+) or Mn(2+) from the cytosol to the Golgi lumen. Its expression during brain development in different types of neurons has been documented recently, which ...