Publicaties
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A Mathematical Model of the Ultrasound-Assisted Continuous Tubular Crystallization of Aspirin KU Leuven
Modeling enzyme controlled metabolic networks in rapidly changing environments by robust optimization KU Leuven
© 2017 IEEE. Constraint-based methods, such as the flux balance analysis (FBA), are widely used to model cellular growth processes without relying on knowledge of regulatory features. Regulation is instead substituted by an optimization problem to maximize a biological objective such as biomass accumulation. A recent extension to these methods is called dynamic enzyme-cost FBA (deFBA). This fully dynamic modeling method allows to predict optimal ...
Dynamic Density Estimation in Heterogeneous Cell Populations KU Leuven
Multicellular systems play a key role in bioprocess and biomedical engineering. Cell ensembles encountered in these setups show phenotypic variability like size and biochemical composition. As this variability may result in undesired effects in bioreactors, close monitoring of the cell population heterogeneity is important for maximum production output, and accurate control. However, direct measurements are mostly restricted to a few cellular ...
Technical Committee on Systems Biology KU Leuven
Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling. KU Leuven
Cellular communication via intracellular signalling pathways is crucial. Expression and activation of signalling proteins is heterogenous between isogenic cells of the same cell-type. However, mechanisms evolved to enable sufficient communication and to ensure cellular functions. We use information theory to clarify mechanisms facilitating IL-6-induced JAK/STAT signalling despite cell-to-cell variability. We show that different mechanisms ...
FOREWORD KU Leuven
Towards the construction of GSMN-based community model for an oral bio film KU Leuven
Oral biofi lms form on all hard and soft surfaces of the oral cavity. When the microbial balance in this biofi lm is disturbed, pathogens can take the overhand, and this can lead to periodontitis (i.e. a chronic and inflammatory disease of the gum and tooth supporting tissues). In this work, a dual species community model containing one commensal bacterium and the most common periopathogen, is presented. The commensal bacterium is Streptococcus ...
A Novel Framework for Parameter and State Estimation of Multicellular Systems Using Gaussian Mixture Approximations KU Leuven
© 2018 by the authors. Multicellular systems play an important role in many biotechnological processes. Typically, these exhibit cell-to-cell variability, which has to be monitored closely for process control and optimization. However, some properties may not be measurable due to technical and financial restrictions. To improve the monitoring, model-based online estimators can be designed for their reconstruction. The multicellular dynamics is ...