Publicaties
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The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function Universiteit Gent Vlaams Instituut voor Biotechnologie
Introduction: Polymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic peroxisome proliferator-activated receptor alpha (PPAR alpha) and glucocorticoid receptor (GR) quickly lose function in sepsis, these metabolites accumulate (causing toxicity) and fail to yield ...
Circulating cell-free DNA in health and disease : the relationship to health behaviours, ageing phenotypes and metabolomics Universiteit Gent Vlaams Instituut voor Biotechnologie
Paneth cells as the cornerstones of intestinal and organismal health : a primer Universiteit Gent Vlaams Instituut voor Biotechnologie
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF Universiteit Gent Vlaams Instituut voor Biotechnologie
The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic cells (DCs) is evident but its physiological significance is unknown. Here we showed that DC-biased precursors depended on the expression of the transcription factor IRF8 to express the membrane-bound precursor form of the cytokine TNF (tmTNF) to promote differentiation of thymus seeding hematopoietic ...
Hepatic peroxisome proliferator-activated receptor alpha dysfunction in porcine septic shock Universiteit Gent Vlaams Instituut voor Biotechnologie
Despite decades of research, sepsis remains one of the most urgent unmet medical needs. Mechanistic investigations into sepsis have mainly focused on targeting inflammatory pathways; however, recent data indicate that sepsis should also be seen as a metabolic disease. Targeting metabolic dysregulations that take place in sepsis might uncover novel therapeutic opportunities. The role of peroxisome proliferator-activated receptor alpha (PPAR ...
Acute endotoxemia-induced respiratory and intestinal dysbiosis Universiteit Gent Vlaams Instituut voor Biotechnologie
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements Universiteit Gent Vlaams Instituut voor Biotechnologie
Validation of a novel multivariate method of defining HIV-associated cognitive impairment Universiteit Gent
Background: The optimum method of defining cognitive impairment in virally suppressed people living with HIV is unknown. We evaluated the relationships between cognitive impairment, including using a novel multivariate method (NMM), patientreported outcome measures (PROMs), and neuroimaging markers of brain structure across 3 cohorts. Methods: Differences in the prevalence of cognitive impairment, PROMs, and neuroimaging data from the COBRA, ...