Publicaties
Host miRNAs as biomarkers of SARS-CoV-2 infection : a critical review Universiteit Gent
A red light-triggered chemical tool for sequence-specific alkylation of G-quadruplex and I-motif DNA Universiteit Gent
The importance of non-canonical DNA structures such as G-quadruplexes (G4) and intercalating-motifs (iMs) in the fine regulation of a variety of cellular processes has been recently demonstrated. As the crucial roles of these structures are being unravelled, it is becoming more and more important to develop tools that allow targeting these structures with the highest possible specificity. While targeting methodologies have been reported for G4s, ...
Acid‐resistant BODIPY amino acids for peptide‐based fluorescence imaging of GPR54 receptors in pancreatic islets Universiteit Gent
Photo-induced crosslinking uncovers an antiparallel strand orientation in heterodimeric (EIAALEK)(3)/(KIAALKE)(3) and (EIAALEK)(3)/(RIAALRE)(3) coiled-coil systems Universiteit Gent
We describe for the first time the co-existence of the parallel and antiparallel conformation of the heterodimeric E3/K3 and E3/R3 coiled-coil systems in solution. The introduction of a furanylated amino acid in the (EIAALEK)(3) sequence allowed, upon photo-induced covalent crosslinking, freezing of the respective coiled-coil complexes present in solution. The occurrence of both parallel and antiparallel conformations in solution was supported ...
Cell surface biotinylation using furan cross-linking chemistry Universiteit Gent
Unlocking the secrets of aptamer-small molecule complexes through NMR spectroscopy Universiteit Gent
Complex electrostatic effects on the selectivity of membrane-permeabilizing cyclic lipopeptides Universiteit Gent
Cyclic lipopeptides (CLiPs) have many biological functions, including the selective permeabilization of target membranes, and technical and medical applications. We studied the anionic CLiP viscosin from Pseudomonas along with a neutral analog, pseudodesmin A, and the cationic viscosin-E2K to better understand electrostatic effects on target selectivity. Calcein leakage from liposomes of anionic phosphatidylglycerol (PG) and ...
Chemical composition of five Tunisian Pinus Species' essential oils and effect of their blends on Otitis infection Universiteit Gent
Many studies reported the chemical composition and the biological activities of Pinus Essential oils (EOs). A few of them were investigated for their antibacterial activity against strains responsible for otitis. The present paper investigated the variation of the chemical composition and the antibacterial activity of the EOs of five Tunisian Pinus species and of their combinations against six bacterial strains responsible for otitis. The EOs' ...