Publicaties
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Polygenic analysis of genetically complex traits for the improvement of industrial yeast strains KU Leuven
Physiology and transcriptome of the polycyclic aromatic hydrocarbon-degrading Sphingomonas sp. LH128 after long-term starvation KU Leuven
The survival, physiology and gene expression profile of the phenanthrene-degrading Sphingomonas sp. LH128 was examined after an extended period of complete nutrient starvation and compared with the non-starved population that had been harvested in exponential phase. After 6 months of starvation in an isotonic solution, only 5% of the initial population formed culturable cells. Microscopic observation of GFP fluorescent cells, however, suggested ...
The antifungal plant defensin HsAFP1 from Heuchera sanguinea induces apoptosis in Candida albicans KU Leuven
Plant defensins are active against plant and human pathogenic fungi (such as Candida albicans) and bakerâs yeast. However, they are nontoxic to human cells, providing a possible source for treatment of fungal infections. In this study, we characterized the mode of action of the antifungal plant defensin HsAFP1 from coral bells by screening the Saccharomyces cerevisiae deletion mutant library for mutants with altered HsAFP1 sensitivity and ...
Preliminary Characterization of the Transcriptional Response of the Porcine Intestinal Cell Line IPEC-J2 to Enterotoxigenic Escherichia coli, Escherichia coli, and E. coli Lipopolysaccharide KU Leuven
IPEC-J2, a promising in vitro model system, is not well characterized especially on the transcriptional level, in contrast to human counterparts. The aim of this study was to characterize the gene expression in IPEC-J2 cells when coincubated with enterotoxigenic Escherichia coli (ETEC), nonpathogenic E. coli, and E. coli endotoxin. Apical infection of polarized IPEC-J2 monolayers caused a time-dependent decrease in transepithelial electrical ...