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Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study KU Leuven

Katja von Hoff, Christine Haberler, Felix Schmitt-Hoffner, Elizabeth Schepke, Teresa de Rojas, Sandra Jacobs, Michal Zapotocky, David Sumerauer, Marta Perek-Polnik, Christelle Dufour, et al.
BACKGROUND: Only few data are available on treatment-associated behavior of distinct rare CNS embryonal tumor entities previously treated as "CNS-primitive neuroectodermal tumors" (CNS-PNET). Respective data on specific entities, including CNS neuroblastoma, FOXR2 activated (CNS NB-FOXR2), and embryonal tumors with multilayered rosettes (ETMR) are needed for development of differentiated treatment strategies. METHODS: Within this retrospective, ...

Neuropathology of genetically defined malformations of cortical development - a systematic literature review Vrije Universiteit Brussel

Stefanie Brock, Filip Cools, Anna Jansen

AIMS: Malformations of cortical development (MCD) include a heterogeneous spectrum of clinical, imaging, molecular and histopathological entities. While the understanding of genetic causes of MCD has improved with the availability of next-generation sequencing modalities, genotype-histopathological correlations remain limited. This is the first systematic review of molecular and neuropathological findings in patients with MCD to provide a ...

The effect of augmented reality on the accuracy and learning curve of external ventricular drain placement Vrije Universiteit Brussel

Frederick Van Gestel, Taylor Frantz, Cédric Gunther Vannerom, Anouk Verhellen, Anthony G Gallagher, Shirley A Elprama, An Jacobs, Ronald Buyl, Michaël Bruneau, Bart Jansen, et al.

OBJECTIVE: The traditional freehand technique for external ventricular drain (EVD) placement is most frequently used, but remains the primary risk factor for inaccurate drain placement. As this procedure could benefit from image guidance, the authors set forth to demonstrate the impact of augmented-reality (AR) assistance on the accuracy and learning curve of EVD placement compared with the freehand technique.

METHODS: Sixteen medical ...

The Contribution of Decreased Muscle Size to Muscle Weakness in Children With Spastic Cerebral Palsy KU Leuven

Britta Hanssen, Nicky Peeters, Ines Vandekerckhove, Nathalie De Beukelaer, Lynn Bar-On, Guy Molenaers, Anja Van Campenhout, Marc Degelaen, Christine Van den Broeck, Patrick Calders, et al.
Muscle weakness is a common clinical symptom in children with spastic cerebral palsy (SCP). It is caused by impaired neural ability and altered intrinsic capacity of the muscles. To define the contribution of decreased muscle size to muscle weakness, two cohorts were recruited in this cross-sectional investigation: 53 children with SCP [median age, 8.2 (IQR, 4.1) years, 19/34 uni/bilateral] and 31 children with a typical development (TD) [median ...

The complex and dynamic interplay between self-esteem, belongingness and physical activity in daily life: An experience sampling study in adolescence and young adulthood KU Leuven

Victor Mazereel, Kristof Vansteelandt, Claudia Menne-Lothman, Jeroen Decoster, Catherine Derom, Evert Thiery, Bart PF Rutten, Nele Jacobs, Jim van Os, Marieke Wichers, et al.
Physical activity has positive effects on self-esteem and sense of belongingness and vice versa. The experience sampling method allows for a level of analysis of the within-subject temporal dynamics of these interactions. We hypothesized that physical activity would predict prospective increases of self-esteem and belongingness in the flow of daily life, and vice versa. Additionally, we hypothesized that belongingness would predict self-esteem ...

Trends in Prevalence and Severity of Pre/Perinatal Cerebral Palsy Among Children Born Preterm From 2004 to 2010: A SCPE Collaboration Study KU Leuven

Catherine Arnaud, Virginie Ehlinger, Malika Delobel-Ayoub, Dana Klapouszczak, Oliver Perra, Owen Hensey, David Neubauer, Katalin Hollody, Daniel Virella, Gija Rackauskaite, et al.
Aim: To report on prevalence of cerebral palsy (CP), severity rates, and types of brain lesions in children born preterm 2004 to 2010 by gestational age groups. Methods: Data from 12 population-based registries of the Surveillance of Cerebral Palsy in Europe network were used. Children with CP were eligible if they were born preterm (<37 weeks of gestational age) between 2004 and 2010, and were at least 4 years at time of registration. ...

Usefulness of the Neutrophil-to-Lymphocyte Ratio as a Predictor of Pneumonia and Urinary Tract Infection Within the First Week After Acute Ischemic Stroke Vrije Universiteit Brussel

Robin Gens, Anissa Ourtani, Aurélie De Vos, Jacques De Keyser, Sylvie De Raedt

Background: A high Neutrophil-to-Lymphocyte ratio (NLR) in patients with acute ischemic stroke (AIS) has been associated with post-stroke infections, but it's role as an early predictive biomarker for post-stroke pneumonia (PSP) and urinary tract infection (UTI) is not clear. Aim: To investigate the usefulness of NLR obtained within 24 h after AIS for predicting PSP and UTI in the first week. Methods: Clinical and laboratory data were ...