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Vitrified-warmed blastocyst transfer on the 5th or 7th day of progesterone supplementation in an artificial cycle

Tijdschriftbijdrage - Tijdschriftartikel

Ondertitel:a randomised controlled trial

Prospective studies comparing different durations of progesterone supplementation before transfer of vitrified-warmed blastocysts in an artificial cycle are lacking. However, in oocyte donation programmes, the sporadic available evidence demonstrates considerable differences in clinical pregnancy rates according to the duration of progesterone administration. This randomised controlled trial (RCT), included 303 patients undergoing a frozen-thawed embryo transfer (FET) of one or two vitrified-warmed blastocyst(s) in an artificial cycle. Randomisation was performed when the endometrial thickness reached ≥7 mm after oestrogen supplementation. One hundred and fifty two patients in group A received 7 d of vaginal micronised progesterone tablets and 151 patients in group B received 5 d of micronised vaginal progesterone before FET. No differences were seen in clinical pregnancy rate between both groups: 42/152 (27.6%) in group A versus 49/151 (32.5%) in group B. Although no statistically significant difference was observed in clinical pregnancy rates, our study was powered to detect an absolute difference of 16%. In this regard, we cannot exclude that smaller, clinically relevant differences might exist and our study did not have the power to detect this. Patients were also not blinded for the intervention, causing a potential bias.

Tijdschrift: Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology
ISSN: 0951-3590
Issue: 10
Volume: 33
Pagina's: 783-786
Aantal pagina's: 4
Jaar van publicatie:2017
Trefwoorden:Adult, Blastocyst, Embryo Implantation/drug effects, Embryo Transfer/methods, Female, Humans, Infant, Newborn, Menstrual Cycle/drug effects, Pregnancy, Pregnancy Rate, Progesterone/therapeutic use, Vitrification