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Impact of different sampling schemes for decision making in soil-transmitted helminthiasis control programs

Tijdschriftbijdrage - Tijdschriftartikel

Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples and smears. Consequentially, the sensitivity of KK-based surveys depends on the number of stool samples per person and the number of smears per sample. Given finite resources, collecting multiple samples and/or smears means screening fewer individuals, thereby lowering the statistical precision of prevalence estimates. Using population-level data from various epidemiological settings, we assessed the performance of different sampling schemes executed within the confines of the same budget. We recommend the use of single-slide KK for determining prevalence of moderate-to-heavy intensity infection and policy decisions for starting and continuing PC; more sensitive sampling schemes may be required for policy decisions involving stopping PC. Our findings highlight that guidelines should include specific guidance on sampling schemes.
Tijdschrift: Journal of Infectious Diseases
ISSN: 0022-1899
Issue: Supplement 5
Volume: 221
Pagina's: S531 - S538
Jaar van publicatie:2020
Trefwoorden:Immunologie, Parageneeskundige wetenschappen , Microbiologie