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Use of histamine metabolites as markers for the treatment of ibs with h1-r antagonists

The invention relates to methods for determining whether treatment with an H1- receptor antagonist is likely to cure a visceral sensitivity disorder in a irritable bowel syndrome (IBS) patient or a functional dyspepsia patient comprising determining whether a body sample of said patient has increased levels of a histamine metabolite relative to levels in a normal tissue sample of a healthy individual, wherein an increase of a histamine metabolite is indicative for the effectivity of a treatment to be performed with said H1-receptor antagonist of said visceral sensitivity disorder.
Octrooi-publicatienummer: WO2017102640
Bron: WIPO
Jaar aanvraag: 2016
Jaar van publicatie: 2017
Status: Aangevraagd
Technologiedomeinen: Analysis of biological materials
Gevalideerd voor IOF-sleutel: Ja