Binding domains directed against GPCR:G protein complexes and uses derived thereof

The present disclosure relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present disclosure relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable of expressing such binding domains. The binding domains of the present disclosure can be used as universal tools for the structural and functional characterization of G-protein coupled receptors in complex with downstream heterotrimeric G proteins and bound to various natural or synthetic ligands, for investigating the dynamic features of G protein activation, as well as for screening and drug discovery efforts that make use of GPCR:G protein complexes.

Octrooi-publicatienummer: US10626154

Jaar aanvraag: 2020

Jaar toekenning: 2020

Gevalideerd voor IOF-sleutel: Ja

Toegewezen aan: Universitaire Associatie Brussel