Flavonol glycosides from the leaves of **Boldoa purpurascens** and their anti-inflammatory properties

Boldoa purpurascens is used in Latin America and the Caribbean as a potent diurectic. Phytochemical analysis has shown the presence of flavonoids and other active compounds. In the present work, three flavonol glycosides were isolated from the leaves of the plant. Their structures have been determined by mass spectrometry and by 1D and 2D NMR analysis as 6-methoxykaempferol-3-O-[a-L-rhamnopyr- anosyl-(1 ! 2)]-b-D-xylopyranoside (1); 3,40,5-trihydroxy-6,7-methylenedioxyflavone-3-O-[a-Lrhamnopyranosyl-( 1 ! 2)]-b-D-glucopyranoside (2); and 3,40,50,5-tetrahydroxy-6,7-methylenedioxy- flavone-3-O-[a-L-rhamnopyranosyl-(1 ! 2)]-b-D-xylopyranoside (3). Compounds 1 and 3 are reported for the first time from nature. The NF-kB luciferase assay showed that these compounds have a partial inhibitory effect on NF-kB activation, compound 2 being the most potent one. In the carrageenan induced paw oedema assay in rats, the flavonoid fraction showed acute anti-inflammatory activity, with the highest percentage of inhibition (75.8%) at a dose of 40 mg/kg.

Jaar van publicatie:2017

Trefwoorden:A1 Journal article

BOF-keylabel:ja

BOF-publication weight:1

CSS-citation score:1

Auteurs:International

Authors from:Higher Education

Toegankelijkheid:Open