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Poly(I:C) as cancer vaccine adjuvant

Tijdschriftbijdrage - Tijdschriftartikel

Ondertitel:knocking on the door of medical breakthroughs
Although cancer vaccination has yielded promising results in patients, the objective response rates are low. The right choice of adjuvant might improve the efficacy. Here, we review the biological rationale, as well as the preclinical and clinical results of polyinosinic:polycytidylic acid and its derivative poly-ICLC as cancer vaccine adjuvants. These synthetic immunological danger signals enhanced vaccine-induced anti-tumor immune responses and contributed to tumor elimination in animal tumor models and patients. Supported by these results, poly-ICLC-containing cancer vaccines are currently extensively studied in the ongoing trials, making it highly plausible that poly-ICLC will be part of the future approved cancer immunotherapies.
Tijdschrift: Pharmacology and therapeutics
ISSN: 0163-7258
Volume: 146
Pagina's: 120 - 131
Jaar van publicatie:2015
Trefwoorden:A1 Journal article
BOF-keylabel:ja
BOF-publication weight:10
CSS-citation score:3
Authors from:Higher Education
Toegankelijkheid:Open