The role of CNOT3 in T cell and cancer development

In this project, we aim to define the role of CNOT3 in the development of T-ALL. We will investigate if CNOT3 loss of function enhances the malignant transformation of Tcells in mouse leukemia models. In relation to this, we will also study the role of CNOT3 in T-cell development and we aim to define the molecular changes aused by loss of CNOT3 in leukemia cells. These results can provide important insights on the role of RNA metabolism in leukemia development.

Jaar van publicatie:2019