Functional representation of the symbol digit modalities test in relapsing remitting multiple sclerosis

BACKGROUND: The Symbol Digit Modalities Test (SDMT) is essential in the screening of cognitive impairments in multiple sclerosis (MS). Methodological adaptions of the SDMT on functional MRI exist, but without specific investigation of more cognitive components of information processing speed (IPS). Additionally, there is only limited data on functional differences between MS-patients and healthy controls (HC).

METHODS: 20 MS-patients and 20 HC were investigated executing the original version of the SDMT on fMRI. We analyzed (1) neural networks as indicated in the methodological adaptions (i.e. frontal (Brodman area BA6, BA9), parietal (BA7), occipital (BA17) and cerebellar), (2) functional activations of cognitive components of IPS and (3) functional differences between MS and HC during SDMT.

RESULTS: MS patients performed worse during the SDMT. Both groups demonstrated activation on each region of interest. Cognitive component of IPS was driven by superior parietal and posterior cerebellar activation. MS-patients showed decreased cingulate activation during SDMT as compared to HC.

CONCLUSION: The original SDMT task revealed comparable fMRI-activation sites as reported for previous adaptions. Cognitive components of IPS depend on superior parietal and medial posterior cerebellar regions known to process visuo-spatial integration and anticipation. Attention related areas in the cingulate cortex were decreased in MS-patients.