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Glyoxylate cycle
Boekbijdrage - Hoofdstuk
Some organisms possess enzymes that allow the net conversion of acetyl-CoA to succinate. This is accomplished by the glyoxylate cycle. The overall reaction of this cycle is:
2 acetyl-CoA + NAD + 2 H2O -> succinate + 2 CoA-SH + NADH + H+
As becomes clear from case studies presented, except from prokaryotes, this pathway does not operate as a real physical cycle but it is generally divided between different subcellular compartments. Besides describing the glyoxylate cycle in different organisms, attention is also paid to the purification of its two key enzymes, isocitrate lyase (ICLase) and malate synthase (MSase), and to their physicochemical, catalytic, and structural properties.
2 acetyl-CoA + NAD + 2 H2O -> succinate + 2 CoA-SH + NADH + H+
As becomes clear from case studies presented, except from prokaryotes, this pathway does not operate as a real physical cycle but it is generally divided between different subcellular compartments. Besides describing the glyoxylate cycle in different organisms, attention is also paid to the purification of its two key enzymes, isocitrate lyase (ICLase) and malate synthase (MSase), and to their physicochemical, catalytic, and structural properties.
Boek: Encyclopedia of Microbiology (volume 5) - 3rd edition
Series: Encyclopedia of Microbiology (volume 5) - 3rd edition
Pagina's: 159-179
Aantal pagina's: 21
Jaar van publicatie:2009
Trefwoorden:glyoxylate cycle, isocitrate lyase, malate synthase