Dissecting Peroxisome-Mediated Signaling Pathways: a New and Exciting Research Field

© 2014 Springer-Verlag Wien. All rights reserved. Peroxisomes are multifunctional organelles that play an important role in the metabolism of lipids and reactive oxygen species. As many cellular signaling functions are regulated via lipids, lipid second messengers, and oxidative stress-related factors, it is not surprising to see that these organelles are increasingly recognized as critical regulators of cellular signaling events. To fulfill these signaling functions, peroxisomes physically and functionally interact with other cell organelles, including mitochondria. Recent progress in the development of tools to visualize and modulate molecular processes at the subcellular level has made it possible to gain a better insight into the potential mechanisms governing peroxisomal signaling. This chapter is intended to provide a comprehensive overview of the tools and strategies that are currently available to study peroxisome-mediated signaling pathways in living cells. To provide the reader with relevant background information, we also highlight key studies that have contributed to our understanding of how peroxisomes may function as important sites of redox-, lipid-, inflammatory-, and viral-mediated signal transduction.

ISBN:3709117879

Jaar van publicatie:2014

Toegankelijkheid:Open