Dysplasia in inflammatory bowel disease

© Springer International Publishing AG, part of Springer Nature 2018. All rights are reserved. Due to the continuous inflamed state of the mucosa, ulcerative colitis and Crohn's disease patients are at risk of developing colorectal cancer at an earlier age and with a poorer prognosis. Hence continuous endoscopic surveillance with sampling of biopsies is necessary to detect the preneoplastic lesions in an early stage. Recently a new endoscopic classification is published, in which the lesions are categorized into invisible and visible dysplasia, of which the latter is subtyped into polypoid and non-polypoid lesions. Histologically these lesions consist of different types, namely, adenomatous, villous, and the more recently discovered serrated dysplasia. The presence of an inflamed mucosa complicates its diagnosis, resulting in a high interobserver variability in the categories indefinite for dysplasia and low-grade dysplasia. Hence the ECCO guidelines recommend to confirm the diagnosis of dysplasia by an expert pathologist in gastrointestinal pathology.

ISBN:9783319895024

Jaar van publicatie:2018