Changes in chromatin structure in curettage specimens identifies high-risk patients in endometrial cancer

Most endometrial carcinoma patients are diagnosed at an early stage with a good prognosis. However, a relatively low fraction with lethal disease constitutes a substantial number of patients due to the high incidence rate. Preoperative identification of patients with high-risk and low-risk for poor outcome is necessary to tailor treatment. Nucleotyping refers to characterisation of cell nuclei by image cytometry, including the assessment of chromatin structure by nuclear texture analysis. This method is a strong prognostic marker in many cancers, but has not been evaluated in preoperative curettage specimens from endometrial carcinoma.

Jaar van publicatie:2017

BOF-keylabel:ja

IOF-keylabel:ja

BOF-publication weight:3

CSS-citation score:1

Auteurs:International

Authors from:Higher Education

Toegankelijkheid:Closed