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Behaviour, speciation and toxicity of metal oxide nano particles in aquatic toxicity testing University of Antwerp

Claudia Schmitt
Systemic Physiological and Ecotoxicological Research (SPHERE)
The use and production of nano particles is increasing steadily, but the knowledge of their environmental behaviour and toxicity is still very scarce. A major drawback in studies that investigate the toxicity of nano particles is the difficulty in determination of actual exposure concentrations, which is caused by e.g. the dynamics of aggregation and dissociation in solutions. The project aims on the investigation of the dynamics and uptake ...

Development of an alternative testing strategy for the fish early life-stage test for predicting chronic toxicity. University of Antwerp

Dries Knapen
Systemic Physiological and Ecotoxicological Research (SPHERE), Veterinary physiology and biochemistry
The main objective of this project is to use a mechanistic framework to develop and propose a high-throughput tiered-testing strategy for screening and prioritizing chemicals for FELS testing (OECD 210).The main objective can be divided into four parts:1) Establish a database of toxicologically relevant FELS-specific AOPs, identify molecular initiating events and subsequent intermediate responses resulting into the apical outcome of interest2) ...

Identification, characterization and validation of modifiers of repeat RNA toxicity in C9orf72 amyotrophic lateral sclerosis (ALS) KU Leuven

Ludo Van Den Bosch
Laboratory for Neurobiology (VIB-KU Leuven)

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the degeneration of upper and lower motor neurons in the motor cortex, brainstem and spinal cord. With an average survival of 3-5 years and a lack of effective therapies, there is a high unmet medical need for new therapeutic interventions. The most frequent genetic cause of both familial (40%) and sporadic ALS (4%) is caused by a non-coding repeat ...

Market-oriented validation of SAFETY96: Method for determining a toxicity and/or growth promotion effect of a treatment or compound Hasselt University

Ann CUYPERS
Environmental Biology
A fast, robust screening test to determine plant toxicity or growth-promoting properties of components such as soil additives, biostimulants, fertilisers and pesticides has been developed and a patent has been filed. A promising market study financed via IOF CONCEPT identified the needs and demands of the market. We used this CONCEPT study as a basis to define the valorisation strategy and to outline the development strategy. In the current IOF ...

Reducing cardiac toxicity after breast cancer radiation and extrapolation towards a proton therapy breast cancer treatment. KU Leuven

Caroline Weltens
Laboratory of Experimental Radiotherapy

The purpose of this research project is to investigate late toxicity after breast cancer radiotherapy, with emphasis on late cardiac toxicity, and to develop techniques to reduce late toxicity as well as dedicated follow-up programs to detect and treat toxicity at an early stage. The first part of this research project will focus on a literature review of the already existing data on late cardiac toxicity after irradiation for breast cancer ...

Investigating fatty acid toxicity in amyotrophic lateral sclerosis KU Leuven

Ludo Van Den Bosch
Laboratory for Neurobiology (VIB-KU Leuven)

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease of the adult motor system. In 2040, the number of ALS patients will increase by 69%, making it urgent to develop new treatments. ALS is characterized by the loss of upper and lower motor neurons, leading to progressive paralysis and, inevitably, death within 3 to 5 years of diagnosis. Hyperexcitability is a common pathologic feature and is associated with a worse ...

Effects of the chemical structure of per- and polyfluoroalkyl substances (PFAS) on the bioaccumulation and toxicity to terrestrial and aquatic plants and invertebrates. University of Antwerp

Lieven Bervoets
Integrated Molecular Plant Physiology Research (IMPRES), Ecosphere
Per- and polyfluoroalkyl substances (PFAS) are synthetic organic compounds that have unique properties which have led to a widespread industrial and commercial use, and subsequent contamination of the environment. The partitioning of PFAS to the abiotic matrices, which are important exposure routes for PFAS in the food chain, depends on chemical-, media- and site-specific characteristics. Organisms residing in polluted ecosystems may accumulate ...

NIPITplus, a multi-cancer blood test to predict immune checkpoint inhibitor response and monitor toxicity Ghent University

Katleen De Preter
Department of Biomolecular Medicine

The last decade, an increasing number of cancer patients is treated with immune checkpoint inhibitors, however accurate minimal-invasive response
prediction tests are lacking. In this project, we will develop the NIPITplus strategy where we perform computational deconvolution and TCR/BCR
indexing on bulk sequencing data of blood samples to estimate the proportions of different immune-cell (sub-)types/clones. The deconvolution will ...