Identification of modifier genes underlying intra-familial phenotypic variability in zebrafish OI models using whole exome sequencing and linkage analysis Ghent University
Clinical variability in OI patients carrying an identical causal variant is frequently observed. This suggests that modifier genes contribute to the phenotypic severity through a network of interactions with the causative gene. Zebrafish is known to be a powerful model to study skeletal disorders . They are highly suitable to study intra-familial variability because of a high level of genomic variation, similarity to human, and because high ...