Analyzing circulating bacterial extracellular vesicles in cancer patients to identify their composition and biomarker potential. Ghent University
Symbiosis between epithelial barriers and their microbial ecosystems has a major impact on local and systemic immune mechanisms, marked by influencing therapy response and clinical outcome in cancer patients. Gram+ and Gram- bacteria release bacterial extracellular vesicles (BEV), nanometer-sized membrane particles transporting nucleic acids, metabolites, proteins and endotoxins. We hypothesize that circulating BEV are, at least partially, ...