Projects
Technology-supported innovative rehabilitation University of Antwerp
PRIMORDIAL – An artificial intelligence (AI) driven prediction model to detect risk factors for medication-related osteonecrosis of the jaws. University of Antwerp
Who is left in the middle? Reproducibility and functional significance of "bilateral" language dominance Ghent University
The most popular way of determining language dominance is to use fMRI to calculate a laterality index (LI), which quantifies the hemispheric asymmetry in task-evoked activity. Participants with a large LI can readily be classified as left or right dominant, but consensus has yet to be reached as to how “symmetrical” activity (small LI) should be treated, a decision virtually every study on language dominance has to face. The resulting ...
Complexity-driven modelling of macro-conditions in patients with Bodily Distress Syndrome Ghent University
The complex adaptive systems perspective might lead to new insights into the bodily distress syndrome (BDS), an umbrella term for disorders which are characterised by symptoms without clear biological cause. It tells us that such symptoms might stem from a disruption of the human regulatory system, which can be observed through a reduced complexity in physiological signals like heart-rate variability (HRV) and micromovements. For example, in ...
Understanding the emergence of consumer-centric energy systems: an agent-based modeling approach KU Leuven
Advances in electricity generation and storage technology, as well as in Information and Communication Technology, have led to a rapid increase of prosumers. This increase in the number of prosumers is driving the proliferation of new consumer-centric energy systems (CCESs). Nevertheless, the emergence of these systems raises a series of challenges that cut across technical, institutional, economic, and social dimensions. A lack of a research ...
The spatial and temporal structure of visual object space in the human brain KU Leuven
Visual object recognition is a crucial ability in many aspects of human interactions with the surrounding environment. Objects are represented in the lateral and ventral occipitotemporal cortex but it has proven to be difficult to distill an integrative view of the complex functional architecture of these regions. Bao et al. (Nature, 2020) proposed a comprehensive map of object space in inferior temporal cortex of monkeys: the inferior ...
Predicting impending beta cell loss and dysglycemia in asymptomatic type 1 diabetes - Validation of minimally invasive markers against the hyperglycemic clamp test. Vrije Universiteit Brussel
the gold standard hyperglycemic clamp test (HCT) in asymptomatic
type 1 diabetes (T1D) in relation to known determinants of disease
progression. This may help to unravel the heterogeneous nature of
pre-T1D. The majority of beta cell loss is hypothesized to occur within
2 years prior to diagnosis. Simultaneously, promising minimally
...
The DNA methylome in Common Variable Immunodeficiencies (CVID): a comprehensive study characterizing its heterogeneity and its role in disease subclassification Ghent University
Common variable immunodeficiencies (CVID) are the most common primary immunodeficiency. The dysfunctional immune system of CVID patients is unable to protect them against infections. A subgroup of the CVID patients develop a severe disease with distinct comorbidities, associated with a poor outcome. In the majority of the CVID no monogenic cause is found. Flow cytometry (FCM) and to a lesser extent genetic analysis are currently used to ...
Omics Data Integration to Predict Drug Resistance in Mycobacterium tuberculosis Vrije Universiteit Brussel
worldwide. Improved diagnosis is essential to address increasing TB
antimicrobial resistance and to assign an effective treatment regimen.
The advent of whole-genome sequencing (WGS) promises to
overcome slow, more expensive, and biohazardous assay
susceptibility testing. However WGS relies on previous
understanding of resistance mechanisms in M. ...