Systematic examination of the effects of Nlgn3 deletion and R451C mutation on PV+ GABAergic interneurons: implications for behavioral phenotypes associated with neurodevelopmental disorders in mice KU Leuven
Using a cell-restricted conditional knockout approach, we will determine the role of the postsynaptic neurexin cell adhesion binding partner neuroligin in PV+ GABAergic interneurons for regulating ASD-relevant behavioral phenotypes. Specifically, we will investigate whether an ASD-associated Nlgn3 deletion or R451C mutation causes behavioral deficits relevant to the core ASD symptoms. For this, we will cross Nlgn3 KO mice (Nlgn3 cKO) and ...