Projects
RF 19/6334 - FLUPOUL - Elucidating the causes of the high prevalence of fluoroquinolone resistance in broilers Ghent University
Since the new legislation in 2016, the use of (fluoro)quinolones in livestock farming has fallen enormously, but unexpectedly high levels of fluoroquinolone resistance in E. coli are still found in broiler chicken farms. Within the FLUPOUL project, research is being done into the possible explanations for this. A cross-sectional study on broiler farms examines the extent to which the environment is a source for the spread of FQ resistance in ...
Trend of fluoroquinolone resistance among the MDR in DF Bangladesh Institute of Tropical Medicine
1. Check whether the proportion of high-level resistance among FQ resistant MDR cases has really increased over the years, and investigate the causes as far as possible:
- Misclassification: not new but previously 2nd-line treated cases
- More import cases from outside the project area in recent years
- Changes in FQ preference of other practitioners in the ...
Trends in fluoroquinolone resistance in new TB patients in Bangladesh and the subsequent rate of acquired drug resistance Institute of Tropical Medicine
The secondary objective is to assess whether patients with baseline FQ resistance without baseline rifampicin resistance experience higher rates of failure due to acquired resistance to non-FQ TB drugs (including ...
EndTB-Q Output 5 testing new regimens to treat MDR-TB resistant to fluoroquinilones Institute of Tropical Medicine
Accurate diagnosis and effective treatment for tuberculosis retreatment patients in Niger Institute of Tropical Medicine
A platform for equitable global access to whole genome sequencing-guided management and control of drug resistant tuberculosis (MAGMA). University of Antwerp
Heteroresistance: an occult threat to the treatment success of resistant tuberculosis Institute of Tropical Medicine
form of TB, with less than 50% of over 0.5 million patients affected
each year reaching successful treatment outcomes. Due to difficulties
in defining the full drug resistance profile in each individual patient,
there is a tremendous risk of losing key classic- (fluoroquinolones)
and new drugs (bedaquiline (BDQ)) at a faster pace than novel ...
Heteroresistance: an occult threat to the treatment success of resistant tuberculosis Acronym "DeepMTB". University of Antwerp
Impact of diagnostic delays and short treatment regimens on outcomes of rifampicin-resistant tuberculosis patients in Cameroon KU Leuven
Rifampicin-resistant tuberculosis (RR-TB) remains a major health challenge in low- and middle-income countries despite availability of diagnostic platforms and treatment options. Despite, increasing, increasing use of rapid molecular tests (e.g., Xpert MTB/RIF or Ultra) for detection of RR-TB globally, there is still a major RR-TB diagnostic gap and low treatment success of those started on treatment. Short injectable-containing regimens ...