Comparative analysis of resistance-fitness evolution in multidrug resistant Candida species: a role for fitness trade-off compensation and hypermutators? KU Leuven
Invasive, multidrug-resistant (MDR) fungal infections pose a growing threat to public health, yet the evolutionary dynamics and mechanisms of resistance in fungi have been largely neglected. Nearly not investigated so far are fitness-resistance trade-offs, fitness trade-off compensatory mechanisms and drug/species specific mutation rates. In this project, we want to conduct a comparative study of antifungal drug resistance evolution in four ...