Projects
Fast metabolite profiles and their data analysis for the prospective study and quality control of plants of pharmaceutical interest Vrije Universiteit Brussel
Chemometrics and metabolite profiles for the prospective study and quality control of plants of pharmaceutical interest: bringing this untapped approach into the field Vrije Universiteit Brussel
Selection of bio-active quinoïds and analysis of a combined chemotherapy and immunoprofylaxis for the control of tuberculosis Ghent University
Quinones are natural products that display a variety of biological activities, amongst which antibiotic and antitumor activity, which makes them valuable for the development of new drugs. Tuberculosis is a serious infectious disease and the rise of multiresistant Mycobacteria necessitates continued research to new active compounds. In this respect, the current research proposal aims at the synthesis and bio-testing against various ...
Co-extrusion electrospinning as novel tool for the next generation wound dressings: taking ultimate control over the dressing mechanical and release properties. Ghent University
In the present project, novel hydrogel-based wound dressings will be developed exhibiting antibacterial properties. To date, two critical issues associated with wound dressings are to be tackled: the inferior mechanical properties and the uncontrolled release of bio-active compounds. The starting materials for developing novel wound dressings will include polysaccharides (i.e. alginate and chitosan) for controlling the moisture content of ...
Effect of bioactive peptides on the cholecystokinin (CCK)-receptor regulating satiety and food intake in humans and insects Ghent University
This project evaluates the potential of bioactive peptides to reduce food intake by interacting with the cholecystokinin (CCK)-receptor. After enzymatich hydrolysis of food proteins, bioactive peptides are isolated and their in vitro activity on the CCK-receptor is determined using a cell bioassay. Moreover, their in vivo satiating effect in rats and their potential in the control of insect pests are evaluated.
Identification and characterisation of novel regulators of the abundance and functioning of the COI1 protein, the receptor of the plant hormone jasmonate Ghent University
Plant fitness and survival depend on the ability and plasticity to adapt developmental and growth
programmes to a 24-hour changing environment, which is safeguarded by complex signalling
networks in which hormones such as the jasmonates play major roles. The bioactive version of the
jasmonate hormone is perceived by the co-receptor complex consisting of the F-box protein
CORONATINE 1 (COI1) and a JAZ ...
Regio- and stereoselective ring expansions of 2-(2-cyanoethyl)aziridines toward functionalized pyrrolidines and piperidines Ghent University
2-(2-Cyanoethyl)aziridines will be deployed for the construction of novel 2-(aminomethyl)pyrrolidines and 3-aminopiperidines via LiAlH4-induced transformations. Special attention will be devoted to the control of the regio- and stereochemistry. This project aims at providing new fundamental insights in the field of aziridine chemistry. In addition, selected target compounds will be evaluated in terms of their potential bioactivity ...
Striking Essential Oil: Novel tools and new insights to study the biological activities of essential oils (EOs) and their components (EOCs) KU Leuven
The increasing level of antimicrobial resistance poses the threat that no suitable antimicrobials will be available for systematic treatment of common diseases. More and more Candida infections are caused by intrinsically and multi-resistant Candida isolates. There is clearly renewed scientific interest in discovering drugs from natural sources, although natural product-based drug discovery is considered intrinsically ...