The search for the origin of chromosomal abnormalities in human preimplantation embryos Vrije Universiteit Brussel
the first cleavages of the embryo. We want to study the ...
We and others have shown that the UPR is significantly activated in colonocytes found in inflammatory lesions in patients with IBD. However, to date, it is not clear whether increased epithelial cell death in IBD results from prolonged UPR responses or whether interfering with the UPR can diminish inflammation. The specific goals of the current proposal are:
- To determine the relationship between UPR activation, mode ...
In tissue engineering, stem cells are used to produce artificial constructs that can improve or replace biological tissue. The production of these constructs often involves a cell culture step, in which cells are multiplied and assembled in ‘micro-tissues’ with desired tissue properties. To ensure product quality, the physical micro-environment of single cells must be well-controlled during this step. Yet, the formation of this ...
Hodgkin lymphoma (HL) accounts for 11-30 % of all lymphomas and is the most common lymphoid neoplasm in adolescents and young adults. The low abundance of Hodgkin/Reed-Sternberg (HRS) cells, the malignant cells in this disease, hampers the elucidation of its pathogenesis. Today, 10-15% of patients will fail first-line therapy and a similar fraction is likely to be overtreated, underscoring the need to better recognize the diversity of HL. ...
Autophagy is an evolutionary conserved degradation process responsible for the removal of superfluous or damaged proteins and organelles. Autophagy maintains cellular health during stress conditions like nutrient or growth-factor depletion and is implicated in many diseases like cancer and neurodegeneration. The endoplasmic reticulum (ER), the major organelle for protein and lipid synthesis and for intracellular Ca2+ storage, plays a central ...