Projects

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Structural biology of Helicobacter pylori virulence factors Vrije Universiteit Brussel

Han Karel Remaut
Department of Bio-engineering Sciences
Helicobacter pylori is a widespread human pathogen that is the leading cause of chronic gastritis and is associated with the development of peptic ulcers and gastric cancer. Current medical guidelines advocate Helicobacter eradication therapy in peptic ulcer disease, low-grade gastric MALT lymphoma and after gastric cancer resection. Because Helicobacter pylori is one of the most significant risk factors for gastric cancer, H. pylori eradication ...

Virulence factors of Bacillus cereus and host-pathogen interactions Ghent University

Mieke Uyttendaele
Department of Food Technology, Safety and Health

Bacillus cereus is one of the key toxigenic foodborne pathogens of concern to modern food industry,
especially for a group of refrigerated foods of extended durability and dry foods. This species
comprises a highly versatile, psychrotrophic and mesophilic, and incredibly armored group of
opportunistic pathogenic bacteria, which directly in the food or once ingested by the human host
may secrete a wide array of harmful ...

The role of bacterial biofilms as a major cause of therapeutic failure in intensive care units (ICU): an in vitro and in vivo study of 'biofilm' virulence factors. University of Antwerp

Louis Maes
Vaccine & Infectious Disease Institute (VAXINFECTIO), Proteinchemistry, proteomics and epigenetic signalling(PPES), Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
Bacterial isolates from intensive care unit patients will be collected from urinary and intravascular catheters and endotracheal tubes. The biofilm phenotype in relation to antibiotic treatment failure will be investigated using molecular biological, bio-imaging techniques and in vitro and in vivo biofilm models. Particular emphasis will be given to Escherichia coli for urinary tract infections (UTI), Pseudomonas aeruginosa for ventilation ...

Identification of novel surface-expressed factors mediating virulence and biofilm formation in methicillin-resistant Staphylococcus aureus Vrije Universiteit Brussel

Jean-Pierre Hernalsteens
Department of Bio-engineering Sciences, Biology
Methicilline-resistant Staphylococcus aureus (MRSA) recently became of the leading causes of hospital-acquired infections (HA) and infections that are acquired in the Community (CA). HA-MRSA and CA-MRSA show major differences in the distribution of toxin and antibiotic resistance genes. The worldwide spread of some HA-MRSA clones may be associated with an increased expression of virulence genes in these bacteria. In addition to a more aggressive ...

Identification of novel surface-expressed factors mediating virulence and biofilm formation in methicillin-resistant Staphylococcus aureus. University of Antwerp

Herman Goossens
Vaccine & Infectious Disease Institute (VAXINFECTIO)
A first objective of the project is the identification of genes encoding novel virulence factors, which are expressed at the bacterial surface of MRSA.A second objective is to study the differences in biofilm-forming capabilities between hospital-acquired (HA) and community-acquired (CA)-MRSA in the presence and absence of antibiotic pressure.A third objective of this project is to find an explanation why certain MRSA clones are highly epidemic.

Gamma-glutamyl transpeptidase as a major virulence factor of Helicobacter suis: mechanisms leading to epithelial cell necrosis and immune modulation Ghent University

Freddy Haesebrouck
Department of Pathology, bacteriology and poultry diseases

Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in humans suffering from gastric disease. We aim to unravel the mechanisms used by this bacterium and its gamma-glutamyl transpeptidase to cause gastric epithelial cell death on one hand and to modulate the host immune response on the other hand.