Prometheus, is an interdisciplinary, translational, research platform focusing on skeletal tissue engineering and technology transfer. Members include the Divisions of Rheumatology, Orthopaedics, Biomechanics, Experimental Medicine and Endocrinology, Prosthetic Dentistry, Bioresponses (Bioscience Engineering), the Department of Materials Engineering (KU Leuven), and the Division of Biomechanics (University of Liège). Consisting of 50+ PhD ...
Tissue Engineering in Ophthalmology: Regenerating the ocular surface using standardized, xeno-free, tissue-engineered conjunctival grafts for conjunctival reconstruction. University of Antwerp
Carbon nanotubes (CNTs) have gained interest in bone tissue engineering (BTE) to provide scaffolds with mechanical strength and to promote adhesion and proliferation of cells as they can mimic the fibrillar extracellular matrix (ECM) morphology. These properties are necessary inorder to promote bone healing of critical size defects or to reduce interface problems with implants. However, the needle-like shape of nanotubes can rupture cell ...
Enzymatic gradients in biomaterials for tissue engineering Ghent University
Biomaterial scaffolds for tissue engineering with gradients in physico-chemical properties will be created by mineralization/crosslinking by incorporating enzymes from natural tissues within hydrogel biomaterials. By combining enzyme , temperature and compositional gradients a wide range of control over the internal structure can be achieved. Such gradients will be realized by casting, bioplotting and electrospinning.
ADIPINJECT: Development for injectable temperature-responsive hydrogels for adipose tissue engineering Ghent University
Injectable solutions for adipose tissue engineering have recently gained increasing attention among others by lipofilling procedures, breast constructions, wound treatment, ... With the aim to meet an urgenet need in the medical field, the present project aims at developing biomimetic, injectable temperature-responsive hydrogel building blocks suitable for adipose tissue regeneration. Biocompatible hydrogel building will be developed and be ...
Fabrication and investigation of new hybrid scaffolds with controlled porous hierarchy for bone tissue engineering Ghent University
The project results will significantly enhance the quality of life in Russia and Europe. Additive manufacturing technologies to be used in the project enable fabrication of tailored-made personalized permanent and biodegradable implants with hierarchical surface and bulk porosities. The biocompatibility of the hybrid scaffolds will be increased using surface functionalization (e.g. CaP and CaCO3 coatings with Si, Sr, proteins, enzymes).
Human embryonic stem cells for bone tissue engineering Ghent University
Pluripotent embryonic stem cells (ES) are able to differentiate into any cell type. The subject of this project is the differentiation of human ES into the osteogenic lineage. The following techniques will be applied: the use of osteogenic media with or without specific growth factors, the use of biomaterials and 3-dimensional cell constructs. If necessary, cells will be selected based on the expression of specific cell surface molecules.