Projects
ATHLETE Fellowship program: Telomere length in childhood and its multiomics signatures Hasselt University
The prenatal exposome and cardiovascular fetal programming: the role of telomere ageing dynamics. Hasselt University
Long-term effects of metal pollution: linking telomere dynamics, biological aging, infection and fitness. University of Antwerp
Transcriptomic profiles related to telomere length within a life course epidemiology context Hasselt University
Early life determinants of healthy ageing during the first two decades of life: from the telomere interactome to clinical phenotypes. Ghent University
The WHO defines health as “a state of complete physical, mental, and social well-being, but not merely as the absence of disease or infirmity”. Ageing starts before birth and depends on factors that operate throughout life, and hence, the concept of healthy ageing also encompasses healthy growing and healthy living. Indeed, disorders in adults often find their origin in risk factors operative in early life. Senescence or biological ageing is ...
Linking mitochondrial and telomere dysfunction in newborn tissues: TP53, SIRT1 and PPARGC1 alpha as a central hub? Hasselt University
Developmental and later life effects of light and noise pollution: physiological stress, telomere dynamics and fitness. University of Antwerp
Early life determinants of healthy ageing during the first two decades of life: from the telomere interactome to clinical phenotypes Hasselt University
Conformationally locked G4-decoy oligonucleotides for selective telomerase inhibition and development of a nucleic acid-based anti-telomerase PROTAC strategy Ghent University
G-Quadruplex (G4) nucleic acids have received increasing attention not only as targets for small molecule or oligonucleotide-based therapeutic strategies but also due their use as therapeutic aptamers (e.g. AS1411, in clinical trials as anti-nucleolin aptamer), given their known binding to transcription factors and other DNA-binding proteins. An exceptionally relevant target in this field is telomerase, an enzyme that is overexpressed in ...