Rapid detection of Mycobacterium tuberculosis resistance to second-line drugs by use of the manual mycobacterium growth indicator tube system Institute of Tropical Medicine Ghent University
Sterilizing activities of novel combinations lacking first- and second-line drugs in a murine model of tuberculosis University of Antwerp
High levels of resistance to second-line anti-tuberculosis drugs among prisoners with pulmonary tuberculosis in Georgia University of Antwerp
Second-line injectable drugs for rifampicin-resistant tuberculosis: better the devil we know? Institute of Tropical Medicine
In its 2020 guidelines for the treatment of rifampicin-resistant TB (RR-TB), the WHO recommends all-oral fluoroquinoLone-based regimens, with bedaquiline replacing the second-line injectable drugs (SLIDs). SLIDs were used for their strong acquired resistance-preventing activity. Data from three cohorts showed acquired bedaquiline resistance ranging between 2.5% and 30.8%, with no protection from a SLID in most cases. If bedaquiline resistance ...
Resistance to second-line anti-tuberculosis drugs among Peruvian multidrug resistant Mycobacterium tuberculosis strains Institute of Tropical Medicine
OBJECTIVES: To determine the drug resistance profiles for quinolones: ciprofloxacin (CFX), ofloxacin (OFX), moxifloxacin (MFX), and gatifloxacin (GFX); and for injectables: kanamycin (KAN), amikacin (AMK), and capreomycin (CAP) in multidrug resistant (MDR) strains. We also investigated the correlation between mutations in rrs, tlyA and gyrA/B genes, and the in vitro resistance to the second-line anti-tuberculosis drugs.
MATERIALS AND ...