Publications
Chosen filters:
Chosen filters:
Review on bovine respiratory syncytial virus and bovine parainfluenza : usual suspects in bovine respiratory disease : a narrative review Ghent University
Bovine Respiratory Syncytial virus (BRSV) and Bovine Parainfluenza 3 virus (BPIV3) are closely related viruses involved in and both important pathogens within bovine respiratory disease (BRD), a major cause of morbidity with economic losses in cattle populations around the world. The two viruses share characteristics such as morphology and replication strategy with each other and with their counterparts in humans, HRSV and HPIV3. Therefore, BRSV ...
Experimental malaria-associated acute respiratory distress syndrome is dependent on the parasite-host combination and coincides with normocyte invasion Institute of Tropical Medicine KU Leuven
BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a complication of malaria with a lethality rate of up to 80% despite anti-malarial treatment. It is characterized by a vast infiltration of leukocytes, microhaemorrhages and vasogenic oedema in the lungs. Previously, a mouse model for MA-ARDS was developed by infection of C57BL/6 mice with the Edinburgh line NK65-E of Plasmodium berghei.
RESULTS: Here, ...
Parameterisation of respiratory impedance in lung cancer patients from forced oscillation lung function test University of Antwerp Ghent University
Objective: This study aims to analyze the contribution and application of forced oscillation technique (FOT) devices in lung cancer assessment. Two devices and corresponding methods can be feasible to distinguish among various degrees of lung tissue heterogeneity. Methods: The outcome respiratory impedance Z(rs) (in terms of resistance R-rs and reactance X-rs) is calculated for FOT and is interpreted in physiological terms by being fitted with a ...
Correlations between measures of ALS respiratory function: is there an alternative to FVC? KU Leuven
Background: An ongoing longitudinal study in six European sites includes a 3-monthly assessment of forced vital capacity (FVC), slow vital capacity (SVC), peak cough flow (PCF), and Sniff nasal inspiratory pressure (SNIP). The aim of this interim analysis was to assess the potential for SNIP to be a surrogate for aerosol generating procedures given COVID-19 related restrictions. Methods: This was a prospective observational study. Patients ...
Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis University of Antwerp
Background Functional Respiratory Imaging (FRI) combines HRCT scans with computational fluid dynamics to provide objective and quantitative information about lung structure and function. FRI has proven its value in pulmonary diseases such as COPD and asthma, but limited studies have focused on cystic fibrosis (CF). This study aims to investigate the relation of multiple FRI parameters to validated imaging parameters and classical respiratory ...
Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome KU Leuven
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a deadly complication of malaria, and its pathophysiology is insufficiently understood. Both in humans and in murine models, MA-ARDS is characterized by marked pulmonary inflammation. We investigated the role of hemozoin in MA-ARDS in C57Bl/6 mice infected with Plasmodium berghei NK65, P. berghei ANKA, and P. chabaudi AS. By quantifying hemozoin in the lungs and measuring the ...
Estimation of respiratory phases during proton radiotherapy from a 4D-CT and Prompt gamma detection profiles KU Leuven
Proton radiotherapy has a potential to provide an effective cancer treatment while sparing greater volume of healthy tissue than the conventional X-ray based radiotherapy. However, in lungs this potential is hindered by motion due to breathing. An important quantity in treatment verification is the correlation between the respiratory phases (RP) and the timing of pencil beam scanning (PBS). In this note, we demonstrate how the RP can be ...
Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases KU Leuven
Rational: Pulmonary function analysis is an important tool in the evaluation of mouse respiratory disease models but much controversy still exists on the validity of some tests. Most commonly used pulmonary function variables of humans are not routinely applied in mice and the question which pulmonary function is optimal for the monitoring of a particular disease model remains largely unanswered. Objective: Our study aimed to delineate the ...
Noninvasive and invasive pulmonary function in mice with obstructive and restrictive respiratory diseases KU Leuven
Pulmonary function analysis has become an important tool in the evaluation of different murine respiratory disease models. It is still unclear however, which test is optimal for a particular disease as the most commonly used pulmonary function variables of humans are not routinely applied in mice. With this study we wanted to delineate the potential and restrictions of several existing pulmonary function techniques and validate some common ...