Mapping the cell and tissue mechanical environment of early osteoarthritis by means of an optical image-based approach KU Leuven
Osteoarthritis (OA) is the most common chronic joint disease. Cartilage degeneration is the hallmark of OA, with associated changes in all other tissues of the joint. To date, OA is the leading cause of disability among elderly, resulting in pain, limited daily activities and a decreased quality of life. To date no known cure or proven strategy exists for reducing progression from early to end-stage OA. Mechanical loading is key regulator of ...