Single cell RNA and small non-coding RNA sequencing to identify biomarkers for pathogenesis and therapy response in type 1 diabetes. KU Leuven
Type 1 diabetes (T1D) is an autoimmune disease resulting from T-cell mediated destruction of the pancreatic beta-cells causing blood glucose dysregulation. We devised a unique method for tolerance restoration in autoimmune diabetic mice using gut delivery of bacteria genetically altered to secrete proinsulin along with the immunoregulatory cytokine IL10. To facilitate clinical translation, profound insights in the mode of action and the ...