Projects
Influence of chronic oligemia on neurovascular defects and their relation to the onset and development of neurodegeneration: in vivo evaluation of neurovascular response capacity and metabolism in an Alzheimer mouse model. KU Leuven
Alzheimer’s Disease (AD) is the most common cause of dementia, and the most common neurodegenerative disease. AD patients suffer from age-dependent accumulation of dysfunctional amyloid and tau proteins, leading to the deterioration of neurons. As the disease progresses, cognitive faculties become impaired, eventually resulting in death 4-10 years after diagnosis. The most important risk factor is age, and to the increasing overall age of ...
The functional meaning of the Notch signaling cascade for neurodegeneration: a translational approach. KU Leuven
Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disease that mainly affects motor neurons. In this disease, motor neuron degeneration is accompanied and aggravated by oligodendroglial pathology and the presence of reactive astrocytes and microglia.
In this PhD thesis, the role of the Notch signaling pathway in ALS was investigated, as this pathway is implicated in several processes that might contribute ...
Mechanisms underlying protein tau-mediated neurodegeneration: combining transgenic mouse models and AAV vectors. KU Leuven
NEURO.GSK3: GSK3 in neuronal plasticity and neurodegeneration: basic mechanisms and pre-clinical assessment. KU Leuven
IL-13 secreting macrophages migrate to the lesion after intraspinal transplantation in contusion spinal cord injury and create a neuroregenerative immune environment that improves functional recovery. Hasselt University
The neuroregenerative effect of human dental pulp stem cells is enhanced by inflammatory preconditioning with soluble factors contained in Leukocyte- and Platelet Rich Fibrin Hasselt University
Neuroprotective and neuroregenerative effects of transplantation of neurotrophic enhanced dental pulp stem cells in ischaemic stroke. Hasselt University
Searching for neuroregenerative strategies in the senescent killifish KU Leuven
Due to the rise in life expectancy, neurodegenerative diseases associated with aging, such as Alzheimer’s and Parkinson’s disease but also glaucoma, show an increasing prevalence. As neuroregenerative capacities are absent in the adult mammalian central nervous system (CNS), brain trauma and neurodegeneration are often permanent and severely diminish life quality of these (older) patients, which immediately highlights a growing socio-economic ...