Projects
The microglial c-'ASC'-ade hypothesis in Alzheimer's disease and related Tauopathies: Microglial ASC inflammasome activation contributes to tau pathology in vivo Hasselt University
The impact of lysosomal Phospholipase D3 deficiency on activated response microglia regulation KU Leuven
The high region specialization and complexity of the brain provides microglia with a multiplicity of signals, requiring different responses. One of these activation states encompasses the activated response microglia (ARM) phenotype that is acquired when microglia surround amyloid plaques in Alzheimer brains. The phenotype is characterized by an increased lipid metabolism, phagocytosis rate, lysosomal protease content and the secretion of ...
Xenotransplantation of iPSC-derived microglia to elucidate the impact of C9orf72 hexanucleotide repeat expansion on neuroinflammation and neurodegeneration. University of Antwerp
Unraveling metabolic features of microglia and macrophages highlighting the role of peroxisomal β-oxidation KU Leuven
Background
All neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis but also rare inherited metabolic diseases have an inflammatory component (1). Microglia, the immune cells of the brain, are pivotal cells in the generation of this inflammatory response to acute and chronic alterations in brain homeostasis (2). These cells convert from a surveying phenotype in ...