Projects
Functional insight in the biogenesis and specificity of the family of outer membrane porins expressed by the bacterial carcinogen Helicobacter pylori Vrije Universiteit Brussel
Structural and functional characterization of Helicobacter pylori outer membrane adhesins and their role in host adaption Vrije Universiteit Brussel
Structure and biogenesis of Helicobacter pylori outer membrane proteins Vrije Universiteit Brussel
Bacterial and host factors involved in gastric colonization and induction of lesions by Helicobacter suis and Helicobacter heilmannii Ghent University
The aims of this project are to investigate how non-Helicobacter pylori helicobacters colonize and damage the stomach of animals and humans. To achieve this, bacterial factors involved in colonization of the gastric mucosa, induction of host cell death and modulation of the host immune response will be characterized.The aims of this project are to investigate how non-Helicobacter pylori helicobacters colonize and damage the stomach of ...
Bacterial and host factors involved in gastric colonization and induction of lesions by Helicobacter suis and Helicobacter heilmannii Ghent University
The aims of this project are to investigate how non-Helicobacter pylori helicobacters colonize and damage the stomach of animals and humans. To achieve this, bacterial factors involved in colonization of the gastric mucosa, induction of host cell death and modulation of the host immune response will be characterized.The aims of this project are to investigate how non-Helicobacter pylori helicobacters colonize and damage the stomach of ...
Diagnosis of Helicobacter Heilmannii sensu stricto infections in dogs, cats and humans Ghent University
Helicobacter (H.) pylori is the most prevalent Helicobacter species colonizing the gastric
mucosa of humans and has been associated with gastritis, peptic ulcer disease and gastric
cancer. This slightly-curved, Gram-negative and microaerophilic gastric bacterium is highly
adapted to the human host and has succeeded to colonize more than 50% of the human
population worldwide. Besides H. pylori, other spiral-shaped ...
Gamma-glutamyl transpeptidase as a major virulence factor of Helicobacter suis: mechanisms leading to epithelial cell necrosis and immune modulation Ghent University
Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in humans suffering from gastric disease. We aim to unravel the mechanisms used by this bacterium and its gamma-glutamyl transpeptidase to cause gastric epithelial cell death on one hand and to modulate the host immune response on the other hand.
Diversity, antimicrobial sensitivity and virulence mechanisms of Helicobacter suis, a pathogen in pigs with zoonotic significance Ghent University
Helicobacter suis is the most prelevant gastric non-Helicobacter pylori Helicobacter in humans with gastric disease. This agent has also been associated with gastric ulceration in pigs, but the exact role of H. suis in gastric pathology in pigs is not clear. The genomic diversity, antimicrobial sensitivity and virulence mechanims of this agent will be studied.
Modulatory effects of the diet and Helicobacter gastritis in the association between high red (processed) meat consumption and oxidative stress. Ghent University
A high consumption of red (processed) meat is associated with a higher risk to develop a range of chronic diseases such as colorectal cancer, cardiovascular disease and diabetes. Although the underlying mechanisms are still not elucidated, oxidative stress following high red (processed) meat consumption could contribute to the onset and progression of these diseases. The Ph.D. thesis of the applying researcher showed that high amounts of ...